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TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517]
LigandBDBM92603
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assays
IC50 110±n/a nM
Citation Bastos, CBooker, MLCelatka, CAClardy, JCCortese, JPatel, VPSkerlj, RWiegand, RCWirth, DF Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase US Patent US8703811 Publication Date 4/22/2014
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517]
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517]
Synonyms:Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative
Type:Enzyme
Mol. Mass.:47311.25
Organism:Plasmodium berghei
Description:A0A509AEH5[100-517]
Residue:418
Sequence:
MKRFDERMNKEKSKHKKVLFFIFSSIVGLYMYFESYNPEFFMYDVFLDFCLNYVDSEVCH
DLFLLLGKYGLLPYDTSNDSVYATSDIKNLNFINPFGVAAGFDKNGICIDSILKLGFSFI
EIGTITPKPQKGNNKPRIFRDVENKSIINACGFNNIGCDKVTENLINFRKKQEEDKLLSK
HIVGVSIGKNKHTENIVDDLKYSIYKIARYADYIAINVSSPNTPGLRDNQESNKLKNIIL
FVKQEINKIEQIGHNGETFWMNTIKKKPLVFVKLAPDLENSEKKKIAQVLLDTGIDGMII
SNTTINKMDIKSFEDKKGGVSGKKLKDLSTNLISDMYIYTNKQIPIIASGGILTGADALE
KIEAGASVCQLYSCLVFNGVKSAIQIKREFNNALYQKGYYNLREAIGKKHSNAKSLKV
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  Blast E-value cutoff:
BDBM92603
n/a
NameBDBM92603
Synonyms:DHOD Inhibitor, 2 | US8703811, 3
TypeSmall molecule
Emp. Form.C18H23NO
Mol. Mass.269.3813
SMILESCCCCCC1CCCc2c(O)c3ccccc3nc12
Structure
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