| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] |
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| Ligand | BDBM120364 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assays |
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| IC50 | >10000±n/a nM |
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| Citation |  Bastos, C; Booker, ML; Celatka, CA; Clardy, JC; Cortese, J; Patel, VP; Skerlj, R; Wiegand, RC; Wirth, DF Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase US Patent US8703811 Publication Date 4/22/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] |
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| Synonyms: | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative |
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| Type: | Enzyme |
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| Mol. Mass.: | 47311.25 |
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| Organism: | Plasmodium berghei |
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| Description: | A0A509AEH5[100-517] |
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| Residue: | 418 |
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| Sequence: | MKRFDERMNKEKSKHKKVLFFIFSSIVGLYMYFESYNPEFFMYDVFLDFCLNYVDSEVCH
DLFLLLGKYGLLPYDTSNDSVYATSDIKNLNFINPFGVAAGFDKNGICIDSILKLGFSFI
EIGTITPKPQKGNNKPRIFRDVENKSIINACGFNNIGCDKVTENLINFRKKQEEDKLLSK
HIVGVSIGKNKHTENIVDDLKYSIYKIARYADYIAINVSSPNTPGLRDNQESNKLKNIIL
FVKQEINKIEQIGHNGETFWMNTIKKKPLVFVKLAPDLENSEKKKIAQVLLDTGIDGMII
SNTTINKMDIKSFEDKKGGVSGKKLKDLSTNLISDMYIYTNKQIPIIASGGILTGADALE
KIEAGASVCQLYSCLVFNGVKSAIQIKREFNNALYQKGYYNLREAIGKKHSNAKSLKV
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| BDBM120364 |
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| n/a |
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| Name | BDBM120364 |
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| Synonyms: | US8703811, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9ClFIN2 |
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| Mol. Mass. | 398.601 |
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| SMILES | Fc1cc(I)ccc1Nc1ccnc2cc(Cl)ccc12 |
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| Structure | 
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