Ki Summary

Reaction Details

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Target

Hormone-sensitive lipase

Ligand

BDBM120374

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Inhibition Assay

7.2±n/a

Temperature

277.15±n/a K

IC50

41.8±n/a nM

Comments

extracted

Citation

Hunziker, D; Neidhart, W Azaspirodecanone compounds US Patent US8703807 Publication Date 4/22/2014

More Info.:

Get all data from this article, Assay Method

Hormone-sensitive lipase

Name:

Hormone-sensitive lipase

Synonyms:

HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN

Type:

Protein

Mol. Mass.:

116599.07

Organism:

Homo sapiens (Human)

Description:

Q05469

Residue:

1076

Sequence:

MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH

BDBM120374

n/a

Name

BDBM120374

Synonyms:

US8703807, 10

Type

Small organic molecule

Emp. Form.

C22H28F3N3O4

Mol. Mass.

455.4706

SMILES

C[C@H](Oc1ccc(cn1)N1CC[C@]2(CC[C@@](O)(CN3CCCC3=O)CC2)C1=O)C(F)(F)F |r,wU:15.16,wD:12.12,1.0,15.17,(6.68,-.75,;7.08,.74,;5.99,1.82,;4.5,1.43,;4.1,-.06,;2.61,-.46,;1.52,.63,;1.92,2.12,;3.41,2.52,;.04,.23,;-.44,-1.23,;-1.98,-1.23,;-2.46,.23,;-2.85,1.72,;-4.34,2.12,;-5.43,1.03,;-6.2,2.36,;-6.97,1.03,;-7.74,-.31,;-7.26,-1.77,;-8.51,-2.68,;-9.76,-1.77,;-9.28,-.31,;-10.05,1.03,;-5.03,-.46,;-3.54,-.86,;-1.21,1.14,;-1.21,2.68,;8.56,1.13,;8.96,2.62,;9.65,.05,;10.05,1.53,)|

Structure