Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM123401 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Radioligand Binding Assay I |
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pH | 7.5±n/a |
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Temperature | 277.15±n/a K |
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Kd | 501±n/a nM |
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Comments | extracted |
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Citation | Badiger, S; Behnke, D; Betschart, C; Chaudhari, V; Chebrolu, M; Cotesta, S; Hintermann, S; Meyer, A; Pandit, C Disubstituted heteroaryl-fused pyridines US Patent US8742106 Publication Date 6/3/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM123401 |
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n/a |
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Name | BDBM123401 |
Synonyms: | US8742106, 6.77 |
Type | Small organic molecule |
Emp. Form. | C25H22F3N3O2 |
Mol. Mass. | 453.4563 |
SMILES | C[C@H](NC(=O)COc1cc(c2c(cn(C)c2n1)-c1ccccc1)C(F)(F)F)c1ccccc1 |r| |
Structure |
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