| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
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| Ligand | BDBM123814 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human MAO inhibitory test |
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| pH | 7.4±0 |
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| Temperature | 310.15±0 K |
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| Ki | 3.78e+4± 1.9e+3 nM |
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| Citation |  Rane, RA; Napahde, S; Bangalore, PK; Sahu, NU; Shah, N; Kulkarni, YA; Barve, K; Lokare, L; Karpoormath, R Synthesis and evaluation of novel marine bromopyrrole alkaloid-based derivatives as potential antidepressant agents. Chem Biol Drug Des84:593-602 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] A |
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| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) |
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| Type: | Protein |
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| Mol. Mass.: | 59689.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21397 |
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| Residue: | 527 |
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| Sequence: | MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
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| BDBM123814 |
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| n/a |
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| Name | BDBM123814 |
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| Synonyms: | 4,5-dibromo-N'-(2-hydroxybenzylidene)-1H-pyrrole-2-carbohydrazide (4a) |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9Br2N3O2 |
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| Mol. Mass. | 387.027 |
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| SMILES | Oc1ccccc1C=NNC(=O)c1cc(Br)c(Br)[nH]1 |w:8.9| |
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| Structure | 
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