| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM123907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 8±n/a nM |
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| Comments | extracted |
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| Citation |  Masuda, K; Kida, S; Yoshikawa, N; Katou, M; Kato, T; Nakajima, M; Kojima, E; Yonehara, M Oxadiazole derivative having endothelial lipase inhibitory activity US Patent US8754113 Publication Date 6/17/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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| BDBM123907 |
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| n/a |
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| Name | BDBM123907 |
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| Synonyms: | US8754113, I-3-48 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N5O3S |
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| Mol. Mass. | 421.472 |
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| SMILES | O=C(Cc1nnc(Cc2nc3ccc(cc3s2)C2=CCOCC2)o1)NC1(CC1)C#N |t:19| |
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| Structure | 
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