| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelial lipase |
|---|
| Ligand | BDBM123915 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 8±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Masuda, K; Kida, S; Yoshikawa, N; Katou, M; Kato, T; Nakajima, M; Kojima, E; Yonehara, M Oxadiazole derivative having endothelial lipase inhibitory activity US Patent US8754113 Publication Date 6/17/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelial lipase |
|---|
| Name: | Endothelial lipase |
|---|
| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56805.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y5X9 |
|---|
| Residue: | 500 |
|---|
| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
|
|
|
|---|
| BDBM123915 |
|---|
| n/a |
|---|
| Name | BDBM123915 |
|---|
| Synonyms: | US8754113, A-10 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H16N6O2S |
|---|
| Mol. Mass. | 416.456 |
|---|
| SMILES | O=C(Cc1nnc(Cc2nc3cnc(cc3s2)-c2ccccc2)o1)NC1(CC1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
