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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | ||
| Ligand | BDBM124518 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Inhibition Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.101±n/a nM | ||
| Comments | extracted | ||
| Citation |  Allen, JR; Biswas, K; Chavez, Jr., F; Chen, N; De Morin, FF; Falsey, JR; Frohn, MJ; Harrington, PE; Home, DB; Harrington, EH; Kaller, MR; Kunz, RK; Monenschein, H; Nguyen, TT; Pickrell, AJ; Reichelt, A; Rumfelt, S; Rzasa, RM; Sham, K; Yao, G Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors US Patent US8759532 Publication Date 6/24/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | |||
| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | 3.1.4.17 | PDE10A | PDE10_HUMAN | Phosphodiesterase 10 (PDE10) | Phosphodiesterase 10A | ||
| Type: | Protein | ||
| Mol. Mass.: | 88412.52 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9Y233 | ||
| Residue: | 1055 | ||
| Sequence: |
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| BDBM124518 | |||
| n/a | |||
| Name | BDBM124518 | ||
| Synonyms: | US8759532, 195 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H23N3O3 | ||
| Mol. Mass. | 413.4684 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r,wU:4.7,wD:1.0,(-6.37,5.39,;-6.37,3.85,;-7.71,3.08,;-7.71,1.54,;-6.37,.77,;-5.04,1.54,;-5.04,3.08,;-6.37,-.77,;-7.71,-1.54,;-7.71,-3.08,;-6.37,-3.85,;-5.04,-3.08,;-5.04,-1.54,;-3.71,-.77,;-2.37,-1.54,;-2.37,-3.08,;-1.04,-3.85,;.29,-3.08,;.29,-1.54,;-1.04,-.77,;1.63,-3.85,;1.63,-5.39,;2.96,-3.08,;3.12,-1.55,;4.63,-1.23,;5.4,.11,;6.94,.11,;7.71,-1.23,;6.94,-2.56,;5.4,-2.56,;4.37,-3.71,)| | ||
| Structure | 
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