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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase mTOR | ||
| Ligand | BDBM127462 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biochemical Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| Ki | 0.404±n/a nM | ||
| Comments | extracted | ||
| Citation |  Cheng, H; Johnson, TW; Hoffman, JE; Guo, LC; Liu, Z Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions US Patent US8791131 Publication Date 7/29/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase mTOR | |||
| Name: | Serine/threonine-protein kinase mTOR | ||
| Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
| Type: | Rapamycin target protein | ||
| Mol. Mass.: | 288917.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P42345 | ||
| Residue: | 2549 | ||
| Sequence: |
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| BDBM127462 | |||
| n/a | |||
| Name | BDBM127462 | ||
| Synonyms: | US8791131, 236 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23N5O2 | ||
| Mol. Mass. | 413.4717 | ||
| SMILES | Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cccc2[nH]ccc12 |r,wU:13.14,wD:16.18,(6.56,-1.53,;5.07,-1.13,;3.92,-2.16,;3.92,-3.7,;2.59,-4.47,;1.26,-3.7,;-.08,-4.47,;-1.41,-3.7,;-1.41,-2.16,;-.08,-1.39,;1.26,-2.16,;2.59,-1.39,;2.91,.12,;1.82,1.2,;.33,.81,;-.75,1.89,;-.36,3.38,;-1.45,4.47,;1.13,3.78,;2.22,2.69,;4.44,.28,;5.21,1.61,;-2.74,-1.39,;-2.74,.15,;-4.08,.92,;-5.41,.15,;-5.41,-1.39,;-6.56,-2.42,;-5.93,-3.83,;-4.4,-3.67,;-4.08,-2.16,)| | ||
| Structure | 
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