| Reaction Details |
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 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Ligand | BDBM138057 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 17±n/a nM |
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| Comments | extracted |
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| Citation |  Motomura, T; Nagamori, H; Suzawa, K; Ito, H; Morita, T; Kobayashi, S; Shinkai, H Fluorene compound and pharmaceutical use thereof US Patent US8871934 Publication Date 10/28/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Synonyms: | PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 46153.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15119 |
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| Residue: | 407 |
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| Sequence: | MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
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| BDBM138057 |
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| n/a |
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| Name | BDBM138057 |
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| Synonyms: | US8871934, 650 | US8871934, 660 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23F3N2O2 |
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| Mol. Mass. | 416.4361 |
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| SMILES | CC(C)(C)Cn1cc(cn1)-c1cc2c(-c3ccccc3C2(O)C(F)(F)F)c(CO)c1 |
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| Structure | 
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