| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM138145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| pH | 5.5±n/a |
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| IC50 | 8.12±n/a nM |
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| Comments | extracted |
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| Citation |  Chaplin, DJ; Gaddale Devanna, KK; Parker, E; Pinney, KG; Song, J; Trawick, ML Compositions and methods for inhibition of cathepsins US Patent US8877967 Publication Date 11/4/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM138145 |
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| n/a |
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| Name | BDBM138145 |
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| Synonyms: | US8877967, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14BrF2N3OS |
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| Mol. Mass. | 474.321 |
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| SMILES | NC(=S)NN=C(c1cc(Br)cc(c1)C(=O)c1ccccc1F)c1ccccc1F |w:4.3| |
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| Structure | 
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