| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM138148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| pH | 6±n/a |
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| IC50 | >10000±n/a nM |
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| Comments | extracted |
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| Citation |  Chaplin, DJ; Gaddale Devanna, KK; Parker, E; Pinney, KG; Song, J; Trawick, ML Compositions and methods for inhibition of cathepsins US Patent US8877967 Publication Date 11/4/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM138148 |
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| n/a |
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| Name | BDBM138148 |
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| Synonyms: | US8877967, 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N3O3S |
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| Mol. Mass. | 405.47 |
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| SMILES | COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:17.19| |
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| Structure | 
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