| Reaction Details |
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 | Report a problem with these data |
| Target | Baculoviral IAP repeat-containing protein 2 |
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| Ligand | BDBM139074 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization (FP) Based Competitive Assay |
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| pH | 7.5±n/a |
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| IC50 | <100±n/a nM |
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| Comments | extracted |
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| Citation |  Wang, S; Sheng, R; Sun, H; Liu, L; Lu, J; McEachern, D Bivalent inhibitors of IAP proteins and therapeutic methods using the same US Patent US8883771 Publication Date 11/11/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Baculoviral IAP repeat-containing protein 2 |
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| Name: | Baculoviral IAP repeat-containing protein 2 |
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| Synonyms: | API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1) | MIHB | RNF48 |
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| Type: | Protein |
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| Mol. Mass.: | 69900.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13490 |
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| Residue: | 618 |
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| Sequence: | MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGV
PVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH
RRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLL
STSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTT
GENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILD
NLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLF
VDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLR
KCPICRGIIKGTVRTFLS
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| BDBM139074 |
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| n/a |
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| Name | BDBM139074 |
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| Synonyms: | US8883771, 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C68H78N12O8S |
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| Mol. Mass. | 1223.488 |
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| SMILES | CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CCC(N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(Sc2ccc(NC(=O)N3CC[C@H]4CC[C@H](N4C(=O)[C@H](C3)NC(=O)[C@H](C)NC)C(=O)NC(c3ccccc3)c3ccccc3)cc2)cc1 |r| |
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| Structure | 
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