| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic |
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| Ligand | BDBM146328 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Biochemical Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 39±n/a nM |
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| Comments | extracted |
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| Citation |  Caferro, TR; Cho, YS; Costales, AQ; Lei, H; Lenoir, F; Levell, JR; Liu, G; Palermo, MG; Pfister, KB; Sendzik, M; Shafer, C; Shultz, MD; Smith, T; Sutton, JC; Toure, B; Yang, F; Zhao, Q 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH US Patent US8957068 Publication Date 2/17/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate dehydrogenase [NADP] cytoplasmic |
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| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic |
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| Synonyms: | Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD |
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| Type: | Protein |
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| Mol. Mass.: | 46661.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75874 |
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| Residue: | 414 |
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| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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| BDBM146328 |
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| n/a |
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| Name | BDBM146328 |
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| Synonyms: | US8957068, 446 | US8957068, 447 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23FN6O3 |
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| Mol. Mass. | 438.4548 |
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| SMILES | CC(C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(Oc3ccc(F)cc3)cn2)n1 |r,w:15.16| |
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| Structure | 
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