Ki Summary

Reaction Details

Report a problem with these data

Target

E3 ubiquitin-protein ligase Mdm2

Ligand

BDBM135199

Substrate/Competitor

n/a

Meas. Tech.

FRET Assay

IC50

1±n/a nM

Citation

Christopher, MP; Fradera Llinas, FX; Machacek, M; Martinez, M; Reutershan, MH; Shizuka, M; Sun, B; Thompson, CF; Trotter, BW; Voss, ME; Altman, MD; Bogen, SL; Doll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent US8962611 Publication Date 2/24/2015

More Info.:

Get all data from this article, Assay Method

E3 ubiquitin-protein ligase Mdm2

Name:

E3 ubiquitin-protein ligase Mdm2

Synonyms:

Type:

Oncoprotein

Mol. Mass.:

55196.54

Organism:

Homo sapiens (Human)

Description:

Q00987

Residue:

491

Sequence:

MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP

BDBM135199

n/a

Name

BDBM135199

Synonyms:

US8846657, 3.92

Type

Small organic molecule

Emp. Form.

C27H31ClFN7O3

Mol. Mass.

556.032

SMILES

CO[C@@H]1C[C@@H](CF)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1 |r,wU:26.29,2.1,wD:29.33,4.4,(7.66,-.13,;6.33,-.9,;4.99,-.13,;4.99,1.41,;3.53,1.88,;2.76,3.21,;3.53,4.55,;2.62,.64,;3.53,-.61,;1.08,.64,;.18,1.88,;-1.29,1.41,;-2.62,2.18,;-3.96,1.41,;-3.96,-.13,;-2.62,-.9,;-2.62,-2.44,;-1.29,-3.21,;-1.29,-4.75,;-2.62,-5.52,;-3.96,-4.75,;-5.29,-5.52,;-3.96,-3.21,;-1.29,-.13,;.18,-.61,;.18,-2.15,;1.51,-2.92,;2.84,-2.15,;4.18,-2.92,;4.18,-4.46,;5.51,-5.23,;2.84,-5.23,;1.51,-4.46,;-5.29,2.18,;-6.75,1.7,;-7.66,2.95,;-6.75,4.19,;-7.52,5.52,;-5.29,3.72,)|

Structure