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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM150187 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Caliper Mobility-Shift Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 303.15±n/a K | ||
| IC50 | 0.719±n/a nM | ||
| Comments | extracted | ||
| Citation |  Wu, Y; Wang, A Heterocyclic substituted pyrimidine compound US Patent US8980904 Publication Date 3/17/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-specific 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
| Type: | Protein | ||
| Mol. Mass.: | 99975.83 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O76074 | ||
| Residue: | 875 | ||
| Sequence: |
| ||
| BDBM150187 | |||
| n/a | |||
| Name | BDBM150187 | ||
| Synonyms: | US8980904, 12 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H33ClN4O4 | ||
| Mol. Mass. | 501.018 | ||
| SMILES | COc1ccc(COc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)CC2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-4.16,;-8.05,-4.93,;-6.72,-4.16,;-5.33,-4.9,;-4,-4.13,;-4,-2.59,;-2.67,-1.82,;-1.33,-2.59,;,-1.82,;,-.28,;1.33,.49,;2.67,-.28,;2.67,-1.82,;1.33,-2.59,;1.33,-4.13,;,-4.9,;2.67,-4.9,;4,-4.13,;4,-2.59,;5.33,-1.82,;6.67,-2.59,;8,-1.82,;6.67,-4.13,;5.33,-4.9,;1.33,2.03,;2.67,2.8,;2.67,4.34,;1.33,5.11,;2.1,6.44,;.56,6.44,;,4.34,;,2.8,;-5.33,-1.82,;-6.67,-2.59,;-8,-1.82,)| | ||
| Structure | 
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