| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM152517 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro AChE Inhibition Assay |
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| pH | 8±n/a |
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| Ki | 3.483e+4± 3.42e+3 nM |
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| IC50 | 1.558e+4± 3e+1 nM |
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| Km | 1280±2540 nM |
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| Comments | extracted |
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| Citation |  Piplani, P; Danta, CC Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers. Bioorg Chem60:64-73 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_MOUSE | Acetylcholinesterase (AChE) | Acetylcholinesterase (mouse AChE) | Acetylcholinesterase precursor | Ache |
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| Type: | Enzyme |
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| Mol. Mass.: | 68165.65 |
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| Organism: | Mus musculus (mouse) |
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| Description: | n/a |
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| Residue: | 614 |
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| Sequence: | MRPPWYPLHTPSLAFPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
IACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
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| BDBM152517 |
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| n/a |
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| Name | BDBM152517 |
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| Synonyms: | N-(4-(2-oxo-2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethoxy)phenyl)acetamide (1f) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N5O3 |
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| Mol. Mass. | 355.391 |
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| SMILES | CC(=O)Nc1ccc(OCC(=O)N2CCN(CC2)c2ncccn2)cc1 |
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| Structure | 
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