| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Decaprenyl diphosphate synthase |
|---|
| Ligand | BDBM50173765 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | DPPS Inhibition (trans FPP based) Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 4.3e+3±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Kim, MO; Feng, X; Feixas, F; Zhu, W; Lindert, S; Bogue, S; Sinko, W; de Oliveira, C; Rao, G; Oldfield, E; McCammon, JA A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery. Chem Biol Drug Des85:756-69 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Decaprenyl diphosphate synthase |
|---|
| Name: | Decaprenyl diphosphate synthase |
|---|
| Synonyms: | DPDS_MYCTO | cis-Decaprenyl diphosphate synthase (cis-DPPS) | uppS |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 33800.02 |
|---|
| Organism: | Mycobacterium tuberculosis H37Rv |
|---|
| Description: | n/a |
|---|
| Residue: | 296 |
|---|
| Sequence: | MARDARKRTSSNFPQLPPAPDDYPTFPDTSTWPVVFPELPAAPYGGPCRPPQHTSKAAAP
RIPADRLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVIDIACGAIELGIKWLSLYAF
STENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWVGSRPRLWRSVINELAVAEEM
TKSNDVITINYCVNYGGRTEITEATREIAREVAAGRLNPERITESTIARHLQRPDIPDVD
LFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACEEYASRTRRFGSA
|
|
|
|---|
| BDBM50173765 |
|---|
| n/a |
|---|
| Name | BDBM50173765 |
|---|
| Synonyms: | BPH-308 | CHEMBL196749 | [2-(2',4'-Difluoro-biphenyl-3-yl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14F2O7P2 |
|---|
| Mol. Mass. | 394.2011 |
|---|
| SMILES | OC(Cc1cccc(c1)-c1ccc(F)cc1F)(P(O)(O)=O)P(O)(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
