Reaction Details |
| Report a problem with these data |
Target | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
---|
Ligand | BDBM153704 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | KinEASE Assay |
---|
IC50 | 9e+2± 2e+2 nM |
---|
Citation | Fang, Z; Simard, JR; Plenker, D; Nguyen, HD; Phan, T; Wolle, P; Baumeister, S; Rauh, D Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. ACS Chem Biol10:279-88 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
---|
Name: | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
Synonyms: | AKT1 | AKT1_HUMAN | PKB | Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) | RAC |
Type: | Protein |
Mol. Mass.: | 55608.09 |
Organism: | Homo sapiens (Human) |
Description: | Human Akt1 containing mutations E49C, C296S, C310S and C344S |
Residue: | 480 |
Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRCAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLSKEGI
KDGATMKTFSGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMSGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
|
|
|
BDBM153704 |
---|
n/a |
---|
Name | BDBM153704 |
Synonyms: | 2-(4-((3,4-Dihydroisoquinolin-2(1H)-yl)methyl)phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one (7c) |
Type | Small organic molecule |
Emp. Form. | C30H25N3O |
Mol. Mass. | 443.539 |
SMILES | O=c1[nH]ccc2nc(-c3ccc(CN4CCc5ccccc5C4)cc3)c(cc12)-c1ccccc1 |
Structure |
|