| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Ligand | BDBM153705 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | iFLik Assay |
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| pH | 7.4±n/a |
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| Kd | 9e+2± 3e+2 nM |
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| Comments | extracted |
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| Citation |  Fang, Z; Simard, JR; Plenker, D; Nguyen, HD; Phan, T; Wolle, P; Baumeister, S; Rauh, D Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. ACS Chem Biol10:279-88 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Name: | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Synonyms: | AKT1 | AKT1_HUMAN | PKB | Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) | RAC |
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| Type: | Protein |
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| Mol. Mass.: | 55608.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Akt1 containing mutations E49C, C296S, C310S and C344S |
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| Residue: | 480 |
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| Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRCAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLSKEGI
KDGATMKTFSGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMSGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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| BDBM153705 |
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| n/a |
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| Name | BDBM153705 |
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| Synonyms: | Methyl 1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl)piperidine-4-carboxylate (7d) |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N3O3 |
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| Mol. Mass. | 453.5323 |
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| SMILES | COC(=O)C1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1 |
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| Structure | 
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