Reaction Details |
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Target | Ileal sodium/bile acid cotransporter |
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Ligand | BDBM159804 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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Temperature | 298.15±n/a K |
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IC50 | 622±n/a nM |
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Comments | extracted |
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Citation | Aquino, CJ; Collins, JL; Cowan, DJ; Wu, Y Chemical compounds US Patent US9040518 Publication Date 5/26/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Ileal sodium/bile acid cotransporter |
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Name: | Ileal sodium/bile acid cotransporter |
Synonyms: | ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal bile acid transporter | Ileal bile acid transporter/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2 | NTCP2_HUMAN | SLC10A2 |
Type: | Enzyme |
Mol. Mass.: | 37714.89 |
Organism: | Homo sapiens (Human) |
Description: | SLC10A2 |
Residue: | 348 |
Sequence: | MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLG
HIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVD
GDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSL
GFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
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BDBM159804 |
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n/a |
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Name | BDBM159804 |
Synonyms: | US9040518, 19 |
Type | Small organic molecule |
Emp. Form. | C25H35NO4S |
Mol. Mass. | 445.615 |
SMILES | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CCCO)c(OC)cc2[C@H](N1)c1ccccc1 |r| |
Structure |
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