| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 |
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| Ligand | BDBM160287 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Flashplate Assay |
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| IC50 | 60±n/a nM |
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| Citation |  Klar, J; Vöhringer, V; Telser, J; Lobell, M; Süβmeier, F; Li, VM; Böttger, M; Golz, S; Lang, D; Schlemmer, K; Schlange, T; Schall, A; Fu, W Hydroxymethylaryl-substituted pyrrolotriazines as ALK1 inhibitors US Patent US9040691 Publication Date 5/26/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase receptor R3 |
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| Name: | Serine/threonine-protein kinase receptor R3 |
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| Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56134.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37023 |
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| Residue: | 503 |
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| Sequence: | MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
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| BDBM160287 |
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| n/a |
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| Name | BDBM160287 |
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| Synonyms: | US9040691, 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N5OS |
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| Mol. Mass. | 351.425 |
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| SMILES | CCc1nc(cs1)-c1cc(-c2ccc(CO)cc2)c2c(N)ncnn12 |
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| Structure | 
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