Compile Data Set for Download or QSAR

Found 2202 hits with Last Name = 'lobell' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM302404 (US9598416, Example 50) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(C)CC2)cn2ncnc(N)c12 Show InChI InChI=1S/C22H26N6OS/c1-14-8-15-10-18(30-21(15)17(9-14)29-3)19-16(11-27-6-4-26(2)5-7-27)12-28-20(19)22(23)24-13-25-28/h8-10,12-13H,4-7,11H2,1-3H3,(H2,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent									US Patent US9598416 (2017) BindingDB Entry DOI: 10.7270/Q2Q2428R
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM302362 (6-[(2-Aminoethoxy)methyl]-5-(7-methoxy-5-methyl-1-...) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN)cn2ncnc(N)c12 Show InChI InChI=1S/C19H21N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-20)8-24-17(16)19(21)22-10-23-24/h5-8,10H,3-4,9,20H2,1-2H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...				US Patent US9598416 (2017) BindingDB Entry DOI: 10.7270/Q2Q2428R
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM302362 (6-[(2-Aminoethoxy)methyl]-5-(7-methoxy-5-methyl-1-...) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN)cn2ncnc(N)c12 Show InChI InChI=1S/C19H21N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-20)8-24-17(16)19(21)22-10-23-24/h5-8,10H,3-4,9,20H2,1-2H3,(H2,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent									US Patent US9598416 (2017) BindingDB Entry DOI: 10.7270/Q2Q2428R
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239621 (US9394309, 147 | US9394309, 74) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM194899 (US9206184, 80) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)c(Cl)n2ncnc(N)c12 Show InChI InChI=1S/C21H21ClN6O2S/c1-11-5-12-7-15(31-19(12)14(6-11)30-2)17-13(8-27-4-3-24-16(29)9-27)20(22)28-18(17)21(23)25-10-26-28/h5-7,10H,3-4,8-9H2,1-2H3,(H,24,29)(H2,23,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.0	22
BAYER INTELLECTUAL PROPERTY GmbH US Patent					Assay Description For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...				US Patent US9206184 (2015) BindingDB Entry DOI: 10.7270/Q2SN07SH
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM302363 (N-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC(C)=O)cn2ncnc(N)c12 Show InChI InChI=1S/C19H19N5O2S/c1-10-4-12-6-15(27-18(12)14(5-10)26-3)16-13(7-21-11(2)25)8-24-17(16)19(20)22-9-23-24/h4-6,8-9H,7H2,1-3H3,(H,21,25)(H2,20,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent									US Patent US9598416 (2017) BindingDB Entry DOI: 10.7270/Q2Q2428R
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227802 (US10047096, 65 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCC(O)C5)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C24H24FN5O3/c1-13-8-16(25)19(10-21(13)32)27-18-4-6-26-23-22(18)24(33)29-20-9-14(2-3-17(20)28-23)11-30-7-5-15(31)12-30/h2-4,6,8-10,15,31-32H,5,7,11-12H2,1H3,(H,29,33)(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.246	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227931 (US10047096, 192 | trans-Ethyl 3-[({4-[(2-fluoro-5-...) Show SMILES CCOC(=O)[C@H]1C[C@@H](C1)NCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1 |r,wU:7.9,wD:5.4,(10.32,4.14,;10.32,2.6,;8.99,1.83,;8.99,.29,;10.32,-.48,;7.65,-.48,;6.17,-.09,;5.77,-1.57,;7.26,-1.97,;4.43,-2.34,;3.66,-3.68,;2.12,-3.68,;1.46,-5.06,;-.08,-5.18,;-.95,-3.91,;-2.45,-4.25,;-3.65,-3.29,;-4.99,-4.06,;-6.32,-3.29,;-6.32,-1.75,;-4.99,-.98,;-4.99,.56,;-6.32,1.33,;-6.32,2.87,;-7.65,3.64,;-7.65,5.18,;-8.99,2.87,;-10.32,3.64,;-8.99,1.33,;-7.65,.56,;-7.65,-.98,;-3.65,-1.75,;-2.45,-.79,;-2.85,.7,;-.95,-1.13,;-.28,-2.52,;1.26,-2.41,)| Show InChI InChI=1S/C27H28FN5O4/c1-3-37-27(36)16-10-17(11-16)30-13-15-4-5-19-22(9-15)33-26(35)24-20(6-7-29-25(24)32-19)31-21-12-23(34)14(2)8-18(21)28/h4-9,12,16-17,30,34H,3,10-11,13H2,1-2H3,(H,33,35)(H2,29,31,32)/t16-,17-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.274	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227801 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5C[C@H](O)C[C@H]5CO)cc4NC(=O)c23)cc1O |r| Show InChI InChI=1S/C25H26FN5O4/c1-13-6-17(26)20(9-22(13)34)28-19-4-5-27-24-23(19)25(35)30-21-7-14(2-3-18(21)29-24)10-31-11-16(33)8-15(31)12-32/h2-7,9,15-16,32-34H,8,10-12H2,1H3,(H,30,35)(H2,27,28,29)/t15-,16+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.287	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM302404 (US9598416, Example 50) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(C)CC2)cn2ncnc(N)c12 Show InChI InChI=1S/C22H26N6OS/c1-14-8-15-10-18(30-21(15)17(9-14)29-3)19-16(11-27-6-4-26(2)5-7-27)12-28-20(19)22(23)24-13-25-28/h8-10,12-13H,4-7,11H2,1-3H3,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...				US Patent US9598416 (2017) BindingDB Entry DOI: 10.7270/Q2Q2428R
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239712 (US9394309, 171) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnn1 Show InChI InChI=1S/C25H18F5N7OS/c1-15-8-16(2)23(36-6-7-37-24(36)13-22(35-37)20-4-3-5-32-34-20)12-21(15)33-25(38)18-9-17(14-31)10-19(11-18)39(26,27,28,29)30/h3-13H,1-2H3,(H,33,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239548 (US9394309, 1) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCNCC2)cc1-n1ccn2nc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C26H25F5N8OS/c1-17-2-3-20(12-24(17)38-8-9-39-25(38)14-23(36-39)19-15-33-34-16-19)35-26(40)18-10-21(37-6-4-32-5-7-37)13-22(11-18)41(27,28,29,30)31/h2-3,8-16,32H,4-7H2,1H3,(H,33,34)(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239557 (US9394309, 10) Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)S(F)(F)(F)(F)F)N3CCNCC3)ccc2C)c2cc(nn12)-c1cn[nH]c1 Show InChI InChI=1S/C27H27F5N8OS/c1-17-3-4-21(11-25(17)39-16-18(2)40-26(39)13-24(37-40)20-14-34-35-15-20)36-27(41)19-9-22(38-7-5-33-6-8-38)12-23(10-19)42(28,29,30,31)32/h3-4,9-16,33H,5-8H2,1-2H3,(H,34,35)(H,36,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239558 (US9394309, 11) Show SMILES CN1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1cc(C)n2nc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C28H29F5N8OS/c1-18-4-5-22(12-26(18)40-17-19(2)41-27(40)14-25(37-41)21-15-34-35-16-21)36-28(42)20-10-23(39-8-6-38(3)7-9-39)13-24(11-20)43(29,30,31,32)33/h4-5,10-17H,6-9H2,1-3H3,(H,34,35)(H,36,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239564 (US9394309, 17) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCNCC2)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C28H26F5N7OS/c1-19-4-5-22(15-26(19)39-11-12-40-27(39)17-25(37-40)20-3-2-6-35-18-20)36-28(41)21-13-23(38-9-7-34-8-10-38)16-24(14-21)42(29,30,31,32)33/h2-6,11-18,34H,7-10H2,1H3,(H,36,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239570 (US9394309, 23) Show SMILES Cc1ccc(NC(=O)c2cc(OCCCN)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H25F5N6O2S/c1-18-5-6-21(14-25(18)37-9-10-38-26(37)16-24(36-38)19-4-2-8-34-17-19)35-27(39)20-12-22(40-11-3-7-33)15-23(13-20)41(28,29,30,31)32/h2,4-6,8-10,12-17H,3,7,11,33H2,1H3,(H,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239583 (US9394309, 36) Show SMILES CN1CCN(Cc2cc(cc(c2)S(F)(F)(F)(F)F)C(=O)Nc2ccc(C)c(c2)-n2ccn3nc(cc23)-c2cccnc2)CC1 Show InChI InChI=1S/C30H30F5N7OS/c1-21-5-6-25(17-28(21)41-12-13-42-29(41)18-27(38-42)23-4-3-7-36-19-23)37-30(43)24-14-22(20-40-10-8-39(2)9-11-40)15-26(16-24)44(31,32,33,34)35/h3-7,12-19H,8-11,20H2,1-2H3,(H,37,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239594 (US9394309, 47) Show SMILES Cc1nccn1-c1cc(cc(c1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C32H31N7O/c1-21-8-9-26(18-29(21)38-13-14-39-30(38)19-28(36-39)23-7-6-10-33-20-23)35-31(40)24-15-25(32(3,4)5)17-27(16-24)37-12-11-34-22(37)2/h6-20H,1-5H3,(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239595 (US9394309, 48) Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C33H37N7O/c1-23-8-9-27(20-30(23)39-15-16-40-31(39)21-29(36-40)24-7-6-10-34-22-24)35-32(41)25-17-26(33(2,3)4)19-28(18-25)38-13-11-37(5)12-14-38/h6-10,15-22H,11-14H2,1-5H3,(H,35,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239596 (US9394309, 49) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)C(C)(C)O)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C31H33N5O2/c1-20-9-10-25(33-29(37)22-14-23(30(2,3)4)16-24(15-22)31(5,6)38)17-27(20)35-12-13-36-28(35)18-26(34-36)21-8-7-11-32-19-21/h7-19,38H,1-6H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239620 (US9394309, 73) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C25H20F5N5OS/c1-16-11-17(2)23(34-9-10-35-24(34)14-22(33-35)19-6-4-8-31-15-19)13-21(16)32-25(36)18-5-3-7-20(12-18)37(26,27,28,29)30/h3-15H,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239658 (US9394309, 114) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)C(C)(C)C)C#N)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C30H28N6O/c1-19-11-20(2)27(35-9-10-36-28(35)16-26(34-36)22-7-6-8-32-18-22)15-25(19)33-29(37)23-12-21(17-31)13-24(14-23)30(3,4)5/h6-16,18H,1-5H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239696 (US9394309, 153) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(CC(N)=O)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H23F5N6O2S/c1-16-8-17(2)24(37-6-7-38-26(37)14-23(36-38)19-4-3-5-34-15-19)13-22(16)35-27(40)20-9-18(11-25(33)39)10-21(12-20)41(28,29,30,31)32/h3-10,12-15H,11H2,1-2H3,(H2,33,39)(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239708 (US9394309, 166) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cncnc1 Show InChI InChI=1S/C25H18F5N7OS/c1-15-5-16(2)23(36-3-4-37-24(36)10-22(35-37)19-12-32-14-33-13-19)9-21(15)34-25(38)18-6-17(11-31)7-20(8-18)39(26,27,28,29)30/h3-10,12-14H,1-2H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM302385 (4-{[4-Amino-5-(5-chloro-7-methoxy-1-benzothiophen-...) Show SMILES COc1cc(Cl)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12 Show InChI InChI=1S/C20H19ClN6O2S/c1-29-14-6-13(21)4-11-5-15(30-19(11)14)17-12(7-26-3-2-23-16(28)9-26)8-27-18(17)20(22)24-10-25-27/h4-6,8,10H,2-3,7,9H2,1H3,(H,23,28)(H2,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent									US Patent US9598416 (2017) BindingDB Entry DOI: 10.7270/Q2Q2428R
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227926 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CNC5CC(O)C5)cc4NC(=O)c23)cc1O |(-9.65,3.64,;-8.32,2.87,;-8.32,1.33,;-6.99,.56,;-6.99,-.98,;-5.65,1.33,;-4.32,.56,;-4.32,-.98,;-5.65,-1.75,;-5.65,-3.29,;-4.32,-4.06,;-2.99,-3.29,;-1.78,-4.25,;-.28,-3.91,;.59,-5.18,;2.12,-5.06,;2.79,-3.68,;4.33,-3.68,;5.1,-2.34,;6.43,-1.57,;7.92,-1.97,;8.32,-.48,;9.65,.29,;6.83,-.09,;1.92,-2.41,;.39,-2.52,;-.28,-1.13,;-1.78,-.79,;-2.18,.7,;-2.99,-1.75,;-5.65,2.87,;-6.99,3.64,;-6.99,5.18,)| Show InChI InChI=1S/C24H24FN5O3/c1-12-6-16(25)19(10-21(12)32)28-18-4-5-26-23-22(18)24(33)30-20-7-13(2-3-17(20)29-23)11-27-14-8-15(31)9-14/h2-7,10,14-15,27,31-32H,8-9,11H2,1H3,(H,30,33)(H2,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.325	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227794 (US10047096, 57 | rac-1-({4-[(2-Fluoro-5-hydroxy-4-...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCCC(C5)C(N)=O)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C26H27FN6O3/c1-14-9-17(27)20(11-22(14)34)30-19-6-7-29-25-23(19)26(36)32-21-10-15(4-5-18(21)31-25)12-33-8-2-3-16(13-33)24(28)35/h4-7,9-11,16,34H,2-3,8,12-13H2,1H3,(H2,28,35)(H,32,36)(H2,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227785 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-[(i...) Show SMILES CC(C)NCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1 Show InChI InChI=1S/C23H24FN5O2/c1-12(2)26-11-14-4-5-16-19(9-14)29-23(31)21-17(6-7-25-22(21)28-16)27-18-10-20(30)13(3)8-15(18)24/h4-10,12,26,30H,11H2,1-3H3,(H,29,31)(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.363	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227814 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN[C@H]5CC[C@H](O)CC5)cc4NC(=O)c23)cc1O |r,wU:22.22,wD:19.18,(-10.46,3.64,;-9.12,2.87,;-9.12,1.33,;-7.79,.56,;-7.79,-.98,;-6.46,1.33,;-5.12,.56,;-5.12,-.98,;-6.46,-1.75,;-6.46,-3.29,;-5.12,-4.06,;-3.79,-3.29,;-2.59,-4.25,;-1.08,-3.91,;-.22,-5.18,;1.32,-5.06,;1.99,-3.68,;3.53,-3.68,;4.3,-2.34,;5.84,-2.34,;6.61,-3.68,;8.15,-3.68,;8.92,-2.34,;10.46,-2.34,;8.15,-1.01,;6.61,-1.01,;1.12,-2.4,;-.42,-2.52,;-1.08,-1.13,;-2.59,-.79,;-2.98,.7,;-3.79,-1.75,;-6.46,2.87,;-7.79,3.64,;-7.79,5.18,)| Show InChI InChI=1S/C26H28FN5O3/c1-14-10-18(27)21(12-23(14)34)30-20-8-9-28-25-24(20)26(35)32-22-11-15(2-7-19(22)31-25)13-29-16-3-5-17(33)6-4-16/h2,7-12,16-17,29,33-34H,3-6,13H2,1H3,(H,32,35)(H2,28,30,31)/t16-,17-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.372	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227902 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[4...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCC(CCO)CC5)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C27H30FN5O3/c1-16-12-19(28)22(14-24(16)35)30-21-4-8-29-26-25(21)27(36)32-23-13-18(2-3-20(23)31-26)15-33-9-5-17(6-10-33)7-11-34/h2-4,8,12-14,17,34-35H,5-7,9-11,15H2,1H3,(H,32,36)(H2,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.388	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227786 (8-{[Ethyl(methyl)amino]methyl}-4-[(2-fluoro-5-hydr...) Show SMILES CCN(C)Cc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1 Show InChI InChI=1S/C23H24FN5O2/c1-4-29(3)12-14-5-6-16-19(10-14)28-23(31)21-17(7-8-25-22(21)27-16)26-18-11-20(30)13(2)9-15(18)24/h5-11,30H,4,12H2,1-3H3,(H,28,31)(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.388	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227799 (US10047096, 62 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCCC(O)CC5)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C26H28FN5O3/c1-15-11-18(27)21(13-23(15)34)29-20-6-8-28-25-24(20)26(35)31-22-12-16(4-5-19(22)30-25)14-32-9-2-3-17(33)7-10-32/h4-6,8,11-13,17,33-34H,2-3,7,9-10,14H2,1H3,(H,31,35)(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.394	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM302365 (4-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12 Show InChI InChI=1S/C21H22N6O2S/c1-12-5-13-7-16(30-20(13)15(6-12)29-2)18-14(8-26-4-3-23-17(28)10-26)9-27-19(18)21(22)24-11-25-27/h5-7,9,11H,3-4,8,10H2,1-2H3,(H,23,28)(H2,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent									US Patent US9598416 (2017) BindingDB Entry DOI: 10.7270/Q2Q2428R
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM302379 (5-(7-Methoxy-5-methyl-1-benzothiophen-2-yl)-6-(pip...) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNCC2)cn2ncnc(N)c12 Show InChI InChI=1S/C21H24N6OS/c1-13-7-14-9-17(29-20(14)16(8-13)28-2)18-15(10-26-5-3-23-4-6-26)11-27-19(18)21(22)24-12-25-27/h7-9,11-12,23H,3-6,10H2,1-2H3,(H2,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent									US Patent US9598416 (2017) BindingDB Entry DOI: 10.7270/Q2Q2428R
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239579 (US9394309, 32) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H24F5N5O2S/c1-17-6-7-21(14-24(17)36-9-10-37-25(36)15-23(35-37)18-5-4-8-33-16-18)34-26(38)19-11-20(27(2,3)39)13-22(12-19)40(28,29,30,31)32/h4-16,39H,1-3H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239697 (US9394309, 154) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(CC(C)(C)O)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H28F5N5O2S/c1-18-10-19(2)26(38-8-9-39-27(38)15-25(37-39)21-6-5-7-35-17-21)14-24(18)36-28(40)22-11-20(16-29(3,4)41)12-23(13-22)42(30,31,32,33)34/h5-15,17,41H,16H2,1-4H3,(H,36,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239561 (US9394309, 14) Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)C(F)(F)F)-n3ccnc3C)ccc2C)c2cc(nn12)-c1cn[nH]c1 Show InChI InChI=1S/C28H23F3N8O/c1-16-4-5-22(11-25(16)38-15-17(2)39-26(38)12-24(36-39)20-13-33-34-14-20)35-27(40)19-8-21(28(29,30)31)10-23(9-19)37-7-6-32-18(37)3/h4-15H,1-3H3,(H,33,34)(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239706 (US9394309, 164) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cncnc1 Show InChI InChI=1S/C24H19F5N6OS/c1-15-8-16(2)22(34-6-7-35-23(34)11-21(33-35)18-12-30-14-31-13-18)10-20(15)32-24(36)17-4-3-5-19(9-17)37(25,26,27,28)29/h3-14H,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239584 (US9394309, 37) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C2(O)CNC2)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H23F5N6O2S/c1-17-4-5-21(12-24(17)37-7-8-38-25(37)13-23(36-38)18-3-2-6-33-14-18)35-26(39)19-9-20(27(40)15-34-16-27)11-22(10-19)41(28,29,30,31)32/h2-14,34,40H,15-16H2,1H3,(H,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239661 (US9394309, 118) Show SMILES Cc1cc(F)c(NC(=O)c2cc(cc(c2)C(C)(C)C)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H25FN6O/c1-18-10-23(30)25(33-28(37)21-11-19(16-31)12-22(13-21)29(2,3)4)14-26(18)35-8-9-36-27(35)15-24(34-36)20-6-5-7-32-17-20/h5-15,17H,1-4H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239691 (US9394309, 148) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C(C)(C)O)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C28H26F5N5O2S/c1-17-10-18(2)25(37-8-9-38-26(37)15-24(36-38)19-6-5-7-34-16-19)14-23(17)35-27(39)20-11-21(28(3,4)40)13-22(12-20)41(29,30,31,32)33/h5-16,40H,1-4H3,(H,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239695 (US9394309, 152) Show SMILES COC(=O)Cc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C28H24F5N5O3S/c1-17-9-18(2)25(37-7-8-38-26(37)15-24(36-38)20-5-4-6-34-16-20)14-23(17)35-28(40)21-10-19(12-27(39)41-3)11-22(13-21)42(29,30,31,32)33/h4-11,13-16H,12H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227765 (8-[(Diethylamino)methyl]-4-[(2-fluoro-5-hydroxy-4-...) Show SMILES CCN(CC)Cc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1 Show InChI InChI=1S/C24H26FN5O2/c1-4-30(5-2)13-15-6-7-17-20(11-15)29-24(32)22-18(8-9-26-23(22)28-17)27-19-12-21(31)14(3)10-16(19)25/h6-12,31H,4-5,13H2,1-3H3,(H,29,32)(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.401	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227906 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CNCCO)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C22H22FN5O3/c1-12-8-14(23)17(10-19(12)30)26-16-4-5-25-21-20(16)22(31)28-18-9-13(11-24-6-7-29)2-3-15(18)27-21/h2-5,8-10,24,29-30H,6-7,11H2,1H3,(H,28,31)(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.407	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227930 (US10047096, 191 | cis-Ethyl 3-[({4-[(2-fluoro-5-hy...) Show SMILES CCOC(=O)[C@@H]1C[C@@H](C1)NCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1 |r,wU:7.9,5.4,(10.32,4.14,;10.32,2.6,;8.99,1.83,;8.99,.29,;10.32,-.48,;7.65,-.48,;6.17,-.09,;5.77,-1.57,;7.26,-1.97,;4.43,-2.34,;3.66,-3.68,;2.12,-3.68,;1.46,-5.06,;-.08,-5.18,;-.95,-3.91,;-2.45,-4.25,;-3.65,-3.29,;-4.99,-4.06,;-6.32,-3.29,;-6.32,-1.75,;-4.99,-.98,;-4.99,.56,;-6.32,1.33,;-6.32,2.87,;-7.65,3.64,;-7.65,5.18,;-8.99,2.87,;-10.32,3.64,;-8.99,1.33,;-7.65,.56,;-7.65,-.98,;-3.65,-1.75,;-2.45,-.79,;-2.85,.7,;-.95,-1.13,;-.28,-2.52,;1.26,-2.41,)| Show InChI InChI=1S/C27H28FN5O4/c1-3-37-27(36)16-10-17(11-16)30-13-15-4-5-19-22(9-15)33-26(35)24-20(6-7-29-25(24)32-19)31-21-12-23(34)14(2)8-18(21)28/h4-9,12,16-17,30,34H,3,10-11,13H2,1-2H3,(H,33,35)(H2,29,31,32)/t16-,17+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.419	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227816 (8-{[(1,3-Dihydroxypropan-2-yl)amino]methyl}-4-[(2-...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CNC(CO)CO)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C23H24FN5O4/c1-12-6-15(24)18(8-20(12)32)27-17-4-5-25-22-21(17)23(33)29-19-7-13(2-3-16(19)28-22)9-26-14(10-30)11-31/h2-8,14,26,30-32H,9-11H2,1H3,(H,29,33)(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.429	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227796 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-[(3...) Show SMILES CC1CCN(Cc2ccc3Nc4nccc(Nc5cc(O)c(C)cc5F)c4C(=O)Nc3c2)CC1O Show InChI InChI=1S/C26H28FN5O3/c1-14-6-8-32(13-23(14)34)12-16-3-4-18-21(10-16)31-26(35)24-19(5-7-28-25(24)30-18)29-20-11-22(33)15(2)9-17(20)27/h3-5,7,9-11,14,23,33-34H,6,8,12-13H2,1-2H3,(H,31,35)(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.432	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227768 (8-[(Ethylamino)methyl]-4-[(2-fluoro-5-hydroxy-4-me...) Show SMILES CCNCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1 Show InChI InChI=1S/C22H22FN5O2/c1-3-24-11-13-4-5-15-18(9-13)28-22(30)20-16(6-7-25-21(20)27-15)26-17-10-19(29)12(2)8-14(17)23/h4-10,24,29H,3,11H2,1-2H3,(H,28,30)(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.448	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227812 (4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-({[...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CNCCc5ccncc5)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C27H25FN6O2/c1-16-12-19(28)22(14-24(16)35)32-21-7-11-31-26-25(21)27(36)34-23-13-18(2-3-20(23)33-26)15-30-10-6-17-4-8-29-9-5-17/h2-5,7-9,11-14,30,35H,6,10,15H2,1H3,(H,34,36)(H2,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.459	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM227771 (8-[(Cyclopentylamino)methyl]-4-[(2-fluoro-5-hydrox...) Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CNC5CCCC5)cc4NC(=O)c23)cc1O Show InChI InChI=1S/C25H26FN5O2/c1-14-10-17(26)20(12-22(14)32)29-19-8-9-27-24-23(19)25(33)31-21-11-15(6-7-18(21)30-24)13-28-16-4-2-3-5-16/h6-12,16,28,32H,2-5,13H2,1H3,(H,31,33)(H2,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.472	n/a	n/a	n/a	n/a	7.0	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...				US Patent US10047096 (2018) BindingDB Entry DOI: 10.7270/Q23R0VW4
					More data for this Ligand-Target Pair

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