Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Orexin/Hypocretin receptor type 1 |
---|
Ligand | BDBM163876 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Radioligand Binding Assay |
---|
Temperature | 313.15±n/a K |
---|
Ki | 4±n/a nM |
---|
Comments | extracted |
---|
Citation | Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Substituted 7-azabicyles and their use as orexin receptor modulators US Patent US9062078 Publication Date 6/23/2015 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Orexin/Hypocretin receptor type 1 |
---|
Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
Type: | Protein |
Mol. Mass.: | 46817.55 |
Organism: | Rattus norvegicus (Rat) |
Description: | P56718 |
Residue: | 416 |
Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
|
|
|
BDBM163876 |
---|
n/a |
---|
Name | BDBM163876 |
Synonyms: | US9062078, 10A | US9062078, 10B | US9062078, 9 | US9475819, 9 | US9637496, 10B | US9695183, 10B |
Type | Small organic molecule |
Emp. Form. | C22H22FN5O2 |
Mol. Mass. | 407.4408 |
SMILES | Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:15:14:12.11:9| |
Structure |
|