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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM166113 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.2±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
| ||
| BDBM166113 | |||
| n/a | |||
| Name | BDBM166113 | ||
| Synonyms: | US9067937, 57 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27N7O | ||
| Mol. Mass. | 429.5175 | ||
| SMILES | CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cnc(nc1)C#N)C(C)=O |r,wU:4.3,wD:7.10,(-.67,5,;-2,4.23,;-3.33,5,;-2,2.69,;-.67,1.93,;.67,2.69,;2,1.93,;2,.38,;.67,-.38,;-.67,.38,;3.33,-.38,;3.33,-1.93,;4.67,-2.69,;4.67,-4.23,;3.33,-5,;2,-4.23,;.67,-5,;-.67,-4.23,;-.67,-2.69,;.67,-1.93,;2,-2.69,;-2,-1.93,;-2,-.38,;-3.33,.38,;-4.67,-.38,;-4.67,-1.93,;-3.33,-2.69,;-6,.38,;-7.34,1.15,;6,-1.93,;7.34,-2.69,;6,-.38,)| | ||
| Structure | 
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