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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM166123 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.2±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
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| BDBM166123 | |||
| n/a | |||
| Name | BDBM166123 | ||
| Synonyms: | US9067937, 67 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H22ClFN4O2 | ||
| Mol. Mass. | 428.887 | ||
| SMILES | CC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](N)CC1)-c1cc(F)c(O)c(Cl)c1 |r,wU:17.19,wD:14.15,(6.67,-1.71,;5.33,-.94,;5.33,.6,;4,-1.71,;4,-3.25,;2.67,-4.02,;1.33,-3.25,;,-4.02,;-1.33,-3.25,;-1.33,-1.71,;,-.94,;1.33,-1.71,;2.67,-.94,;2.67,.94,;1.33,1.71,;1.33,3.25,;,4.02,;-1.33,3.25,;-2.67,4.02,;-1.33,1.71,;,.94,;-2.67,-.94,;-4,-1.71,;-5.33,-.94,;-6.67,-1.71,;-5.33,.6,;-6.67,1.37,;-4,1.37,;-4,2.91,;-2.67,.6,)| | ||
| Structure | 
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