Ki Summary

Reaction Details

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Target

Maternal embryonic leucine zipper kinase

Ligand

BDBM166135

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

1.6±n/a nM

Comments

extracted

Citation

Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015

More Info.:

Get all data from this article, Assay Method

Maternal embryonic leucine zipper kinase

Name:

Maternal embryonic leucine zipper kinase

Synonyms:

KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)

Type:

Enzyme

Mol. Mass.:

74665.45

Organism:

Homo sapiens (Human)

Description:

Q14680

Residue:

651

Sequence:

MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV

BDBM166135

n/a

Name

BDBM166135

Synonyms:

US9067937, 79

Type

Small organic molecule

Emp. Form.

C27H31Cl2N5O3

Mol. Mass.

544.473

SMILES

CC(C)C(N)C(=O)N[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O |r,wU:11.14,wD:8.7,(-.49,6.72,;.6,5.63,;2.08,6.03,;.2,4.14,;1.29,3.05,;-1.29,3.74,;-2.38,4.83,;-1.69,2.26,;-.6,1.17,;-1,-.32,;.09,-1.41,;1.58,-1.01,;1.98,.48,;.89,1.57,;2.67,-2.1,;2.67,-3.64,;4,-4.41,;4,-5.95,;2.67,-6.72,;1.33,-5.95,;,-6.72,;-1.33,-5.95,;-1.33,-4.41,;,-3.64,;1.33,-4.41,;-2.67,-3.64,;-2.67,-2.1,;-4,-1.33,;-4,.21,;-5.33,-2.1,;-6.67,-1.33,;-5.33,-3.64,;-6.67,-4.41,;-4,-4.41,;5.33,-3.64,;6.67,-4.41,;5.33,-2.1,)|

Structure