Reaction Details | |||
---|---|---|---|
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Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM166156 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1.3±n/a nM | ||
Comments | extracted | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
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BDBM166156 | |||
n/a | |||
Name | BDBM166156 | ||
Synonyms: | US9067937, 204 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H28ClFN4O3 | ||
Mol. Mass. | 486.966 | ||
SMILES | CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(F)c(O)c(Cl)c1)C(=O)CO |r,wU:7.10,wD:4.3,(-3.05,5.78,;-1.96,4.69,;-.47,5.09,;-2.36,3.2,;-1.27,2.11,;-1.66,.62,;-.58,-.47,;.91,-.07,;1.31,1.42,;.22,2.51,;2,-1.16,;2,-2.7,;3.33,-3.47,;3.33,-5.01,;2,-5.78,;.67,-5.01,;-.67,-5.78,;-2,-5.01,;-2,-3.47,;-.67,-2.7,;.67,-3.47,;-3.33,-2.7,;-4.67,-3.47,;-6,-2.7,;-7.34,-3.47,;-6,-1.16,;-7.34,-.39,;-4.67,-.39,;-4.67,1.15,;-3.33,-1.16,;4.67,-2.7,;4.67,-1.16,;6,-3.47,;7.34,-2.7,)| | ||
Structure | ![]() |