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TargetMaternal embryonic leucine zipper kinase
LigandBDBM166164
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 1.6±n/a nM
Commentsextracted
Citation Matsuo, YHisada, SNakamura, YAhmed, FWalker, JRHuntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015
More Info.:Get all data from this article,  Assay Method
 
Maternal embryonic leucine zipper kinase
Name:Maternal embryonic leucine zipper kinase
Synonyms:KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:Enzyme
Mol. Mass.:74665.45
Organism:Homo sapiens (Human)
Description:Q14680
Residue:651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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  Blast E-value cutoff:
BDBM166164
n/a
NameBDBM166164
Synonyms:US9067937, 212
TypeSmall organic molecule
Emp. Form.C28H32ClFN4O2
Mol. Mass.511.031
SMILESCN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(F)c(O)c(Cl)c1)C(=O)C1CCC1 |r,wU:7.10,wD:4.3,(-4.94,5,;-3.61,4.23,;-2.28,5.01,;-3.61,2.69,;-2.28,1.92,;-2.28,.38,;-.94,-.39,;.39,.38,;.39,1.92,;-.94,2.69,;1.72,-.39,;1.72,-1.93,;3.06,-2.7,;3.06,-4.24,;1.72,-5.01,;.39,-4.24,;-.94,-5.01,;-2.28,-4.24,;-2.28,-2.7,;-.94,-1.93,;.39,-2.7,;-3.61,-1.93,;-4.94,-2.7,;-6.28,-1.93,;-7.61,-2.7,;-6.28,-.39,;-7.61,.38,;-4.94,.38,;-4.94,1.92,;-3.61,-.39,;4.39,-1.93,;4.39,-.39,;5.73,-2.7,;6.12,-4.18,;7.61,-3.78,;7.21,-2.3,)|
Structure
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