Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM166164 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1.6±n/a nM | ||
Comments | extracted | ||
Citation | Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
| ||
BDBM166164 | |||
n/a | |||
Name | BDBM166164 | ||
Synonyms: | US9067937, 212 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H32ClFN4O2 | ||
Mol. Mass. | 511.031 | ||
SMILES | CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(F)c(O)c(Cl)c1)C(=O)C1CCC1 |r,wU:7.10,wD:4.3,(-4.94,5,;-3.61,4.23,;-2.28,5.01,;-3.61,2.69,;-2.28,1.92,;-2.28,.38,;-.94,-.39,;.39,.38,;.39,1.92,;-.94,2.69,;1.72,-.39,;1.72,-1.93,;3.06,-2.7,;3.06,-4.24,;1.72,-5.01,;.39,-4.24,;-.94,-5.01,;-2.28,-4.24,;-2.28,-2.7,;-.94,-1.93,;.39,-2.7,;-3.61,-1.93,;-4.94,-2.7,;-6.28,-1.93,;-7.61,-2.7,;-6.28,-.39,;-7.61,.38,;-4.94,.38,;-4.94,1.92,;-3.61,-.39,;4.39,-1.93,;4.39,-.39,;5.73,-2.7,;6.12,-4.18,;7.61,-3.78,;7.21,-2.3,)| | ||
Structure |