Ki Summary

Reaction Details

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Target

Plasminogen activator inhibitor 1

Ligand

BDBM175546

Substrate/Competitor

n/a

Meas. Tech.

Fluorometric Plate Assay

7.8±n/a

Temperature

296.15±n/a K

IC50

50±n/a nM

Comments

extracted

Citation

Lawrence, DA; Emal, C; Cale, J; Su, EJ; Warnock, M; Li, S; Cupp, JA Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism US Patent US9120744 Publication Date 9/1/2015

More Info.:

Get all data from this article, Assay Method

Plasminogen activator inhibitor 1

Name:

Plasminogen activator inhibitor 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

45064.00

Organism:

Homo sapiens (Human)

Description:

P05121

Residue:

402

Sequence:

MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP

BDBM175546

n/a

Name

BDBM175546

Synonyms:

US9120744, CDE-061

Type

Small organic molecule

Emp. Form.

C20H20O10

Mol. Mass.

420.3668

SMILES

Oc1cc(cc(O)c1O)C(=O)O[C@H]1CC[C@H](CC1)OC(=O)c1cc(O)c(O)c(O)c1 |r,wU:15.19,12.12,(6.67,-5.39,;6.67,-3.85,;5.33,-3.08,;5.33,-1.54,;6.67,-.77,;8,-1.54,;9.34,-.77,;8,-3.08,;9.34,-3.85,;4,-.77,;4,.77,;2.67,-1.54,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;,1.54,;1.33,.77,;-2.67,1.54,;-4,.77,;-4,-.77,;-5.33,1.54,;-6.67,.77,;-8,1.54,;-9.34,.77,;-8,3.08,;-9.34,3.85,;-6.67,3.85,;-6.67,5.39,;-5.33,3.08,)|

Structure