Ki Summary

Reaction Details

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Target

Maternal embryonic leucine zipper kinase

Ligand

BDBM176817

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

2.6±n/a nM

Comments

extracted

Citation

Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015

More Info.:

Get all data from this article, Assay Method

Maternal embryonic leucine zipper kinase

Name:

Maternal embryonic leucine zipper kinase

Synonyms:

KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)

Type:

Enzyme

Mol. Mass.:

74665.45

Organism:

Homo sapiens (Human)

Description:

Q14680

Residue:

651

Sequence:

MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV

BDBM176817

n/a

Name

BDBM176817

Synonyms:

US9120749, 185(a) | US9120749, 185(b)

Type

Small organic molecule

Emp. Form.

C30H36ClN3O3

Mol. Mass.

522.078

SMILES

CCN(CC)C1CCC(CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(OC)c1)C(=O)C1CC1 |(-2.66,5.78,;-1.57,4.69,;-1.97,3.2,;-3.45,2.8,;-4.54,3.89,;-.88,2.11,;-1.28,.62,;-.19,-.47,;1.3,-.07,;1.7,1.42,;.61,2.51,;2.39,-1.16,;2.39,-2.7,;3.72,-3.47,;3.72,-5.01,;2.39,-5.78,;1.06,-5.01,;-.28,-5.78,;-1.61,-5.01,;-1.61,-3.47,;-.28,-2.7,;1.06,-3.47,;-2.95,-2.7,;-2.95,-1.16,;-4.28,-.39,;-4.28,1.15,;-5.61,-1.16,;-6.95,-.39,;-5.61,-2.7,;-6.95,-3.47,;-8.28,-2.7,;-4.28,-3.47,;5.06,-2.7,;5.06,-1.16,;6.39,-3.47,;7.16,-4.8,;7.93,-3.47,)|

Structure