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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM177267 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.6±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
| ||
| BDBM177267 | |||
| n/a | |||
| Name | BDBM177267 | ||
| Synonyms: | US9120749, 633 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H36ClN3O4 | ||
| Mol. Mass. | 538.078 | ||
| SMILES | COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(N[C@H]3CC[C@H](CN(C)CCO)CC3)c2c1 |r,wU:24.25,wD:27.29,(-8.11,-1.93,;-6.77,-2.7,;-5.44,-1.93,;-4.1,-2.7,;-2.77,-1.93,;-2.77,-.39,;-4.1,.38,;-4.1,1.92,;-5.44,-.39,;-6.77,.38,;-1.44,-2.7,;-1.44,-4.24,;-.1,-5.01,;1.23,-4.24,;2.56,-5.01,;3.9,-4.24,;3.9,-2.7,;5.23,-1.92,;5.23,-.38,;6.57,-2.69,;7.34,-4.03,;8.11,-2.69,;2.56,-1.93,;2.56,-.39,;1.23,.38,;-.1,-.39,;-1.44,.38,;-1.44,1.92,;-2.77,2.7,;-2.77,4.24,;-4.1,5.01,;-1.44,5.01,;-.1,4.24,;1.23,5.01,;-.1,2.69,;1.23,1.92,;1.23,-2.7,;-.1,-1.92,)| | ||
| Structure | 
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