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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM177309 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 830±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
| ||
| BDBM177309 | |||
| n/a | |||
| Name | BDBM177309 | ||
| Synonyms: | US9120749, 675 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H29ClF3N3O2 | ||
| Mol. Mass. | 544.008 | ||
| SMILES | Oc1c(F)cc(cc1Cl)-c1ccc2ncc(C(=O)C3CC3)c(NC3CCC(CC3)N3CCC(F)(F)C3)c2c1 |(-7.44,-.11,;-6.1,-.88,;-6.1,-2.42,;-7.44,-3.19,;-4.77,-3.19,;-3.44,-2.42,;-3.44,-.88,;-4.77,-.11,;-4.77,1.43,;-2.1,-3.19,;-2.1,-4.73,;-.77,-5.5,;.56,-4.73,;1.9,-5.5,;3.23,-4.73,;3.23,-3.19,;4.56,-2.42,;4.56,-.88,;5.9,-3.19,;6.67,-4.52,;7.44,-3.19,;1.9,-2.42,;1.9,-.88,;.81,.21,;1.21,1.7,;.12,2.79,;-1.37,2.39,;-1.77,.9,;-.68,-.19,;-2.46,3.48,;-2.44,5.02,;-3.91,5.5,;-4.81,4.25,;-6.15,5.02,;-6.15,3.48,;-3.91,3,;.56,-3.19,;-.77,-2.42,)| | ||
| Structure | 
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