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TargetMaternal embryonic leucine zipper kinase
LigandBDBM177406
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 2.1±n/a nM
Commentsextracted
Citation Matsuo, YHisada, SNakamura, YAhmed, FHuntley, RWalker, JRDecornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015
More Info.:Get all data from this article,  Assay Method
 
Maternal embryonic leucine zipper kinase
Name:Maternal embryonic leucine zipper kinase
Synonyms:KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:Enzyme
Mol. Mass.:74665.45
Organism:Homo sapiens (Human)
Description:Q14680
Residue:651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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  Blast E-value cutoff:
BDBM177406
n/a
NameBDBM177406
Synonyms:US9120749, 772
TypeSmall organic molecule
Emp. Form.C28H32Cl2N4O2
Mol. Mass.527.485
SMILESCC(=O)c1cnc2ccc(cc2c1N[C@H]1CC[C@H](CN2CCNCC2)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:14.15,wD:17.19,(6.67,-3.97,;5.33,-3.2,;5.33,-1.66,;4,-3.97,;4,-5.51,;2.67,-6.28,;1.33,-5.51,;,-6.28,;-1.33,-5.51,;-1.33,-3.97,;,-3.2,;1.33,-3.97,;2.67,-3.2,;2.67,-1.42,;1.33,-.65,;,-1.42,;-1.33,-.65,;-1.33,.89,;-2.67,1.66,;-2.67,3.2,;-1.33,3.97,;-1.33,5.51,;-2.67,6.28,;-4,5.51,;-4,3.97,;,1.66,;1.33,.89,;-2.67,-3.2,;-2.67,-1.66,;-4,-.89,;-4,.65,;-5.33,-1.66,;-6.67,-.89,;-5.33,-3.2,;-6.67,-3.97,;-4,-3.97,)|
Structure
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