Reaction Details | |||
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Report a problem with these data | |||
Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM177406 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 2.1±n/a nM | ||
Comments | extracted | ||
Citation | Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
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BDBM177406 | |||
n/a | |||
Name | BDBM177406 | ||
Synonyms: | US9120749, 772 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H32Cl2N4O2 | ||
Mol. Mass. | 527.485 | ||
SMILES | CC(=O)c1cnc2ccc(cc2c1N[C@H]1CC[C@H](CN2CCNCC2)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:14.15,wD:17.19,(6.67,-3.97,;5.33,-3.2,;5.33,-1.66,;4,-3.97,;4,-5.51,;2.67,-6.28,;1.33,-5.51,;,-6.28,;-1.33,-5.51,;-1.33,-3.97,;,-3.2,;1.33,-3.97,;2.67,-3.2,;2.67,-1.42,;1.33,-.65,;,-1.42,;-1.33,-.65,;-1.33,.89,;-2.67,1.66,;-2.67,3.2,;-1.33,3.97,;-1.33,5.51,;-2.67,6.28,;-4,5.51,;-4,3.97,;,1.66,;1.33,.89,;-2.67,-3.2,;-2.67,-1.66,;-4,-.89,;-4,.65,;-5.33,-1.66,;-6.67,-.89,;-5.33,-3.2,;-6.67,-3.97,;-4,-3.97,)| | ||
Structure |