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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM186163 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Scintillation Proximity Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.15±n/a nM | ||
| Comments | extracted | ||
| Citation |  Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| BDBM186163 | |||
| n/a | |||
| Name | BDBM186163 | ||
| Synonyms: | US9163012, 26, Isomer 1a | US9163012, 26, Isomer 1b | US9163012, 26, Isomer 2 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H25ClN4O3 | ||
| Mol. Mass. | 404.891 | ||
| SMILES | NC(=O)C12CC3CC(C1)C(OC(=O)N1CCC(C1)c1ncc(Cl)cn1)C(C3)C2 |TLB:6:7:27:4.5.26,6:5:27:7.9.8,THB:9:7:4:27.25.26,9:25:4:7.6.8,10:9:27:4.5.26,(-8.83,-1.01,;-7.49,-1.78,;-7.49,-3.32,;-6.16,-1.01,;-6.99,-2.91,;-5.6,-2.27,;-4.39,-2.93,;-3.5,-1.01,;-4.82,-1.78,;-3.5,.53,;-2.16,1.3,;-.83,.53,;-.83,-1.01,;.51,1.3,;.51,2.84,;1.97,3.32,;2.87,2.07,;1.97,.83,;4.36,1.67,;4.76,.19,;6.25,-.21,;7.34,.88,;8.83,.48,;6.94,2.36,;5.45,2.76,;-4.82,1.3,;-5.58,.14,;-6.16,.53,)| | ||
| Structure | 
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