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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM186110 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Scintillation Proximity Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 3.69±n/a nM | ||
| Comments | extracted | ||
| Citation |  Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM186110 | |||
| n/a | |||
| Name | BDBM186110 | ||
| Synonyms: | US9163012, 28 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H25ClN4O5 | ||
| Mol. Mass. | 436.889 | ||
| SMILES | O[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)Nc1ncc(Cl)cc1[N+]([O-])=O)C(C3)C2 |r,wU:7.8,14.17,wD:1.0,TLB:4:5:29:2.3.28,4:3:29:5.7.6,THB:7:5:2:29.27.28,7:27:2:5.4.6,8:7:29:2.3.28,(-9.3,-3.09,;-7.97,-2.32,;-8.8,-4.22,;-7.41,-3.58,;-6.2,-4.25,;-5.31,-2.32,;-6.63,-3.09,;-5.31,-.78,;-3.97,-.01,;-2.64,-.78,;-2.64,-2.32,;-1.3,-.01,;-1.3,1.53,;.16,2,;1.07,.76,;.16,-.49,;2.61,.76,;3.38,-.58,;2.29,-1.67,;2.68,-3.15,;4.17,-3.55,;4.57,-5.04,;5.26,-2.46,;4.95,-.87,;6.04,.22,;7.53,-.17,;5.63,1.71,;-6.63,-.01,;-7.39,-1.18,;-7.97,-.78,)| | ||
| Structure | 
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