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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM186126 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Scintillation Proximity Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 5.72±n/a nM | ||
| Comments | extracted | ||
| Citation |  Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| BDBM186126 | |||
| n/a | |||
| Name | BDBM186126 | ||
| Synonyms: | US9163012, 43, Isomer 1 | US9163012, 43, Isomer 2 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H30N4O3 | ||
| Mol. Mass. | 398.4986 | ||
| SMILES | Cc1cc(C)nc(n1)C1CCN(C1)C(=O)OC1C2CC3CC1CC(C3)(C2)C(N)=O |TLB:15:16:22:24.19.20,16:17:24:22.21.20,THB:16:21:24:17.18.25,18:17:22:24.19.20,18:19:22:17.16.25,(8.43,3.39,;7.34,2.3,;7.74,.81,;6.65,-.28,;7.05,-1.77,;5.16,.12,;4.76,1.61,;5.85,2.7,;3.27,2,;2.37,3.25,;.9,2.77,;.9,1.23,;2.37,.76,;-.43,.46,;-.43,-1.08,;-1.76,1.23,;-3.1,.46,;-3.1,-1.08,;-3.99,-3,;-5.2,-2.33,;-5.18,.07,;-4.43,1.23,;-5.76,.46,;-5.76,-1.08,;-6.59,-2.98,;-4.43,-1.85,;-7.09,-1.85,;-8.43,-1.08,;-7.09,-3.39,)| | ||
| Structure | 
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