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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM186131 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Scintillation Proximity Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 2.7±n/a nM | ||
| Comments | extracted | ||
| Citation |  Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM186131 | |||
| n/a | |||
| Name | BDBM186131 | ||
| Synonyms: | US9163012, 48, Isomer 1 | US9163012, 48, Isomer 2 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25F3N4O3 | ||
| Mol. Mass. | 438.4434 | ||
| SMILES | NC(=O)C12CC3CC(C1)C(OC(=O)N1CCC(C1)c1nccc(n1)C(F)(F)F)C(C3)C2 |TLB:29:28:8:5.6.4,THB:4:5:9:8.3.30,4:3:9:5.6.29,29:5:8:28.9.30,10:9:8:5.6.4,(-8.83,-2.39,;-7.49,-3.16,;-7.49,-4.7,;-6.16,-2.39,;-6.99,-4.29,;-5.6,-3.64,;-5.58,-1.24,;-4.83,-.08,;-6.16,-.85,;-3.5,-.85,;-2.16,-.08,;-.83,-.85,;-.83,-2.39,;.5,-.08,;.5,1.46,;1.97,1.94,;2.87,.69,;1.97,-.55,;4.41,.69,;5.18,-.64,;6.72,-.64,;7.49,.69,;6.72,2.03,;5.18,2.03,;7.49,3.36,;8.26,4.7,;6.16,4.13,;8.83,2.59,;-3.5,-2.39,;-4.39,-4.31,;-4.83,-3.16,)| | ||
| Structure | 
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