Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM186133 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Scintillation Proximity Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.91±n/a nM | ||
Comments | extracted | ||
Citation | Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM186133 | |||
n/a | |||
Name | BDBM186133 | ||
Synonyms: | US9163012, 50 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H27N3O2S | ||
Mol. Mass. | 409.544 | ||
SMILES | O=C(OC1C2CC3CC(C2)CC1C3)N1CCC[C@@H]1c1nc(cs1)-c1ccncc1 |r,wD:17.21,TLB:2:3:5:7.8.9,THB:3:11:7:5.4.9,3:4:7:11.10.12,10:11:5:7.8.9,10:8:5:11.3.12,(1.07,2.19,;1.47,3.68,;.38,4.77,;-1.11,4.37,;-2.19,5.46,;-3.68,5.06,;-4.08,3.57,;-5.38,1.95,;-3.86,2.21,;-3.22,4.53,;-2.87,1.26,;-1.51,2.88,;-2.99,2.48,;2.96,4.08,;3.86,5.32,;5.33,4.85,;5.33,3.31,;3.86,2.83,;3.09,1.5,;4,.25,;3.09,-.99,;1.63,-.52,;1.63,1.02,;3.49,-2.48,;2.4,-3.57,;2.8,-5.06,;4.29,-5.46,;5.38,-4.37,;4.98,-2.88,)| | ||
Structure |