Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM186134 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Scintillation Proximity Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.7±n/a nM | ||
Comments | extracted | ||
Citation | Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM186134 | |||
n/a | |||
Name | BDBM186134 | ||
Synonyms: | US9163012, 51 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H27N3O2S | ||
Mol. Mass. | 409.544 | ||
SMILES | O=C(OC1C2CC3CC(C2)CC1C3)N1CCC(C1)c1nc(cs1)-c1ccncc1 |TLB:2:3:5:7.8.9,THB:3:11:7:5.4.9,3:4:7:11.10.12,10:11:5:7.8.9,10:8:5:11.3.12,(-2.99,-.8,;-2.59,.69,;-3.68,1.78,;-5.17,1.38,;-6.25,2.47,;-7.74,2.07,;-8.14,.58,;-9.43,-1.04,;-7.92,-.78,;-7.28,1.54,;-6.93,-1.73,;-5.56,-.11,;-7.05,-.51,;-1.1,1.09,;-.2,2.33,;1.27,1.86,;1.27,.32,;-.2,-.16,;2.6,-.45,;4.07,.02,;4.97,-1.22,;4.07,-2.47,;2.6,-1.99,;6.46,-.82,;7.55,-1.91,;9.03,-1.51,;9.43,-.03,;8.34,1.06,;6.86,.66,)| | ||
Structure |