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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM186135 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Scintillation Proximity Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.19±n/a nM | ||
| Comments | extracted | ||
| Citation |  Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM186135 | |||
| n/a | |||
| Name | BDBM186135 | ||
| Synonyms: | US9163012, 52 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H27N3O3S | ||
| Mol. Mass. | 425.544 | ||
| SMILES | [O-][n+]1ccc(cc1)-c1csc(n1)[C@H]1CCCN1C(=O)OC1C2CC3CC(C2)CC1C3 |r,wD:12.13,TLB:19:20:22:24.25.26,THB:20:28:24:22.21.26,20:21:24:28.27.29,27:28:22:24.25.26,27:25:22:28.20.29,(9.6,-12.72,;9.2,-11.23,;7.71,-10.83,;7.31,-9.34,;8.4,-8.25,;9.89,-8.65,;10.29,-10.14,;8,-6.77,;6.54,-6.29,;6.54,-4.75,;8,-4.27,;8.91,-5.52,;8.77,-2.94,;10.24,-2.47,;10.24,-.93,;8.77,-.45,;7.87,-1.7,;6.38,-2.09,;5.98,-3.58,;5.29,-1.01,;3.8,-1.4,;2.85,-.2,;1.32,-.44,;.76,-1.87,;-.7,-3.34,;.83,-3.25,;1.72,-1.02,;1.71,-4.31,;3.24,-2.84,;1.73,-3.07,)| | ||
| Structure | 
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