| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM123891 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| pH | 8±n/a |
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| IC50 | <10±n/a nM |
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| Comments | extracted |
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| Citation |  Tora, GO; Finlay, H; Hu, CH; Jiang, J; Johnson, JA; Kim, S; Lloyd, J; Parkhurst, B; Pi, Z; Qiao, JX; Wang, TC Ketone linked benzothiazole inhibitors of endothelial lipase US Patent US9169240 Publication Date 10/27/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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|
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| BDBM123891 |
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| n/a |
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| Name | BDBM123891 |
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| Synonyms: | US8754113, I-1-85 | US9169240, 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N5O3S2 |
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| Mol. Mass. | 401.463 |
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| SMILES | NS(=O)(=O)NCc1nnc(Cc2nc3ccc(cc3s2)-c2ccccc2)o1 |
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| Structure | 
|
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