Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [A677G] | ||
Ligand | BDBM190210 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 2.2±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [A677G] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [A677G] | ||
Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A677G) | KMT6 | ||
Type: | Protein | ||
Mol. Mass.: | 85381.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[A677G] | ||
Residue: | 746 | ||
Sequence: |
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BDBM190210 | |||
n/a | |||
Name | BDBM190210 | ||
Synonyms: | EPZ008989 | US9175331, 46 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H37ClF2N4O2 | ||
Mol. Mass. | 523.058 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)CC(F)F)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(-4.67,1.93,;-4.67,.38,;-3.33,-.38,;-3.33,-1.93,;-2,-2.69,;-2,-4.23,;-3.33,-5,;-4.67,-4.23,;-4.67,-2.69,;-3.33,-6.54,;-2,-7.31,;-4.67,-7.31,;-4.67,-8.85,;-6,-9.63,;-3.33,-9.63,;-2,.38,;-.67,-.38,;.67,.38,;2,-.38,;.67,1.93,;-.67,2.69,;-.67,4.23,;-2,5,;.67,5,;.67,6.54,;2,7.31,;2,8.85,;.67,9.63,;3.33,9.63,;4.67,8.85,;6,9.63,;4.67,7.31,;3.33,6.54,;3.33,5,;-2,1.93,;-3.33,2.69,)| | ||
Structure |