Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
Ligand | BDBM190185 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 3.2±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [A687V] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A687V) | KMT6 | ||
Type: | Protein | ||
Mol. Mass.: | 85395.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[A687V] | ||
Residue: | 746 | ||
Sequence: |
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BDBM190185 | |||
n/a | |||
Name | BDBM190185 | ||
Synonyms: | EPZ007038 | US9175331, 11 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H36ClN4O2 | ||
Mol. Mass. | 472.043 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)nc2=O)c1C |r,wU:3.2,wD:6.9,(-5.33,4.23,;-5.33,2.69,;-4,1.93,;-4,.38,;-2.67,-.38,;-2.67,-1.93,;-4,-2.69,;-5.33,-1.93,;-5.33,-.38,;-4,-4.23,;-2.67,-5,;-5.33,-5,;-2.67,2.69,;-2.67,4.23,;-1.33,5,;-1.33,6.54,;,4.23,;,2.69,;1.33,1.93,;2.67,2.69,;1.33,.38,;2.67,-.38,;2.67,-1.93,;4,-2.69,;5.33,-1.93,;4,-4.23,;2.67,-5,;2.67,-6.54,;1.33,-4.23,;1.33,-2.69,;,-1.93,;-1.33,1.93,;-1.33,.38,)| | ||
Structure |