| Reaction Details |
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 | Report a problem with these data |
| Target | Sortilin |
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| Ligand | BDBM159271 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | hSortilin Affinity Assay |
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| pH | 7.4±n/a |
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| Ki | 1144±n/a nM |
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| IC50 | 1200±n/a nM |
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| Comments | extracted |
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| Citation |  Maltas, PJ; Watson, S; Langg{hacek over (a)}rd, M; David, L N-substituted-5-substituted phthalamic acids as sortilin inhibitors US Patent US9682967 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sortilin |
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| Name: | Sortilin |
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| Synonyms: | Neurotensin receptor 3 | SORT1 | SORT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92054.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1282402 |
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| Residue: | 831 |
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| Sequence: | MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGL
RAAAAGGAFPRGGRWRRSAPGEDEECGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDS
TGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSG
KVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLW
VSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIG
VKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDM
VFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLS
EDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLS
EPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHS
SRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSY
TIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVT
KQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPG
DKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKK
YVCGGRFLVHRYSVLQQHAEANGVDGVDALDTASHTNKSGYHDDSDEDLLE
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| BDBM159271 |
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| n/a |
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| Name | BDBM159271 |
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| Synonyms: | US10195186, Example 49 | US9682967, 47 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10F6N2O3 |
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| Mol. Mass. | 392.2526 |
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| SMILES | Cc1cccc(NC(=O)c2cc(c(cc2C(O)=O)C(F)(F)F)C(F)(F)F)n1 |
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| Structure | 
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