| Reaction Details |
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 | Report a problem with these data |
| Target | Complement factor B |
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| Ligand | BDBM289450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human Complement Factor B TR-FRET Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 120±n/a nM |
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| Comments | extracted |
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| Citation |  Adams, CM; Capparelli, MP; Ehara, T; Karki, RG; Mainolfi, N; Zhang, C Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof US Patent US10093663 Publication Date 10/9/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement factor B |
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| Name: | Complement factor B |
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| Synonyms: | BF | BFD | CFAB_HUMAN | CFB |
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| Type: | Enzyme |
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| Mol. Mass.: | 85537.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00751 |
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| Residue: | 764 |
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| Sequence: | MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
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| BDBM289450 |
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| n/a |
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| Name | BDBM289450 |
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| Synonyms: | US10093663, Example 17-2 | US10093663, Example 17-5 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N2O2 |
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| Mol. Mass. | 388.502 |
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| SMILES | Cc1cc(C2CC2)c(CN2CCCCC2c2ccc(cc2)C(O)=O)c2cc[nH]c12 |
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| Structure | 
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