| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM210934 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DHFR Inhibition Assay |
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| IC50 | 17± 2 nM |
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| Citation |  Reeve, SM; Scocchera, EW; G-Dayanadan, N; Keshipeddy, S; Krucinska, J; Hajian, B; Ferreira, J; Nailor, M; Aeschlimann, J; Wright, DL; Anderson, AC MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol23:1458-1467 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA |
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| Type: | Enzyme |
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| Mol. Mass.: | 18249.71 |
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| Organism: | Staphylococcus aureus |
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| Description: | n/a |
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| Residue: | 159 |
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| Sequence: | MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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| BDBM210934 |
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| n/a |
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| Name | BDBM210934 |
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| Synonyms: | UCP1206 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N4O4 |
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| Mol. Mass. | 430.4559 |
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| SMILES | CCc1nc(N)nc(N)c1C#C[C@H](C)c1cc2OCOc2c(c1)-c1ccc(cc1)C(O)=O |r| |
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| Structure | 
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