Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM210934 |
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Substrate/Competitor | n/a |
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Meas. Tech. | DHFR Inhibition Assay |
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IC50 | 1.9e+2± 1e+1 nM |
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Citation | Reeve, SM; Scocchera, EW; G-Dayanadan, N; Keshipeddy, S; Krucinska, J; Hajian, B; Ferreira, J; Nailor, M; Aeschlimann, J; Wright, DL; Anderson, AC MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol23:1458-1467 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Dihydrofolate reductase (DfrG) |
Type: | Protein |
Mol. Mass.: | 19690.71 |
Organism: | Staphylococcus aureus |
Description: | Q4H3Y3 |
Residue: | 165 |
Sequence: | MKVSLIAAMDKNRVIGKENDIPWRIPKDWEYVKNTTKGHPIILGRKNLESIGRALPDRRN
IILTRDKGFTFNGCEIVHSIEDVFELCKNEEEIFIFGGEQIYNLFFPYVEKMYITKIHHE
FEGDTFFPEVNYEEWNEVFAQKGIKNDKNPYNYYFHVYERKNLLS
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BDBM210934 |
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n/a |
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Name | BDBM210934 |
Synonyms: | UCP1206 |
Type | Small organic molecule |
Emp. Form. | C24H22N4O4 |
Mol. Mass. | 430.4559 |
SMILES | CCc1nc(N)nc(N)c1C#C[C@H](C)c1cc2OCOc2c(c1)-c1ccc(cc1)C(O)=O |r| |
Structure |
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