Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM210929 |
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Substrate/Competitor | n/a |
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Meas. Tech. | DHFR Inhibition Assay |
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IC50 | 30± 1 nM |
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Citation | Reeve, SM; Scocchera, EW; G-Dayanadan, N; Keshipeddy, S; Krucinska, J; Hajian, B; Ferreira, J; Nailor, M; Aeschlimann, J; Wright, DL; Anderson, AC MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol23:1458-1467 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Dihydrofolate reductase (DfrK) |
Type: | Protein |
Mol. Mass.: | 19251.04 |
Organism: | Staphylococcus aureus |
Description: | C7C2U7 |
Residue: | 163 |
Sequence: | MKVSLIAAMDKNRVIGKENDIPWRIPEDWEYVKNTTKGYPIILGRKNLESIGRALPGRRN
IILTRDKGFSFNGCEIVHSIEDVFELCNSEEEIFIFGGEQIYNLFLPYVEKMYITKIHYE
FEGDTFFPEVNYEEWNEVSVTQGITNEKNPYTYYFHIYERKAS
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BDBM210929 |
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n/a |
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Name | BDBM210929 |
Synonyms: | UCP1172 |
Type | Small organic molecule |
Emp. Form. | C24H24N4O3 |
Mol. Mass. | 416.4724 |
SMILES | CCc1nc(N)nc(N)c1C#C[C@@H](C)c1cc(OC)cc(c1)-c1ccc(cc1)C(O)=O |r| |
Structure |
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