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Reaction Details
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TargetDihydrofolate reductase
LigandBDBM210929
Substrate/Competitorn/a
Meas. Tech.DHFR Inhibition Assay
IC50 30± 1 nM
Citation Reeve, SMScocchera, EWG-Dayanadan, NKeshipeddy, SKrucinska, JHajian, BFerreira, JNailor, MAeschlimann, JWright, DLAnderson, AC MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol23:1458-1467 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DfrK)
Type:Protein
Mol. Mass.:19251.04
Organism:Staphylococcus aureus
Description:C7C2U7
Residue:163
Sequence:
MKVSLIAAMDKNRVIGKENDIPWRIPEDWEYVKNTTKGYPIILGRKNLESIGRALPGRRN
IILTRDKGFSFNGCEIVHSIEDVFELCNSEEEIFIFGGEQIYNLFLPYVEKMYITKIHYE
FEGDTFFPEVNYEEWNEVSVTQGITNEKNPYTYYFHIYERKAS
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BDBM210929
n/a
NameBDBM210929
Synonyms:UCP1172
TypeSmall organic molecule
Emp. Form.C24H24N4O3
Mol. Mass.416.4724
SMILESCCc1nc(N)nc(N)c1C#C[C@@H](C)c1cc(OC)cc(c1)-c1ccc(cc1)C(O)=O |r|
Structure
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