| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 [1-454] |
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| Ligand | BDBM210885 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Quench Assay |
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| pH | 4.4±n/a |
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| IC50 | 37±n/a nM |
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| Comments | extracted |
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| Citation |  Venkatraman, S; Yuan, J; Zheng, Y Inhibitors of β-secretase US Patent US9290477 Publication Date 3/22/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-secretase 1 [1-454] |
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| Name: | Beta-secretase 1 [1-454] |
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| Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE1) | KIAA1149 |
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| Type: | Protein |
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| Mol. Mass.: | 50294.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human BACE1 truncation (1-454 aa) |
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| Residue: | 454 |
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| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDEST
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| BDBM210885 |
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| n/a |
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| Name | BDBM210885 |
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| Synonyms: | US9290477, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N4O |
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| Mol. Mass. | 336.4308 |
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| SMILES | C[C@H]1C[C@]2(Cc3ccc(cc3[C@@]22N=C(C)C(N)=N2)[N+]#[C-])C[C@@H](C)[C@@H]1O |r,c:18,t:14| |
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| Structure | 
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